Study of Candida Albicans Mannoprotien Immunomodulatory Effect on Immune Response in Mice Vaccinated with Hbs Vaccine

A study was conducted to determine the effect of the Candida albicans mannoprotein on Phagocytic activity, antibody production, serum gammaglobuline percentage and lymphocyte transformation index after vaccination with hepatitis B surface (HBs) antigen. It can be concluded that Mannoprotein isolated from Candida albicans cell wall are an important immunomodulatorts in the development of immune response against HBs antigen vaccine. The results demonstrated a clear immunomodulatory effect of the mannoproteins of Candida albicans cell wall (improvement of non-specific, cellular and humoral immune response) of the treated mice which Compared to the first three groups of mice(negative and positive controls), others groups that were immunized with combination of vaccines and candida albicans mannoprotein revealed higher serum anti-HBs level and a significance increased in Phagocytic activity and lymphocyte proliferation percentage.